Thomas M. Maddox, MD SM

Professor of Medicine; Director of Clinical Innovation, WashU Medicine

Thomas M. Maddox is a cardiologist, physician executive, and clinical informatician focused on advancing care delivery through digital transformation, artificial intelligence, and operational redesign. As Director of Clinical Innovation for the Department of Medicine at WashU Medicine, he leads efforts to improve care delivery across WashU DOM and Barnes-Jewish Hospital through the deployment of Epic, digital tools, predictive analytics, and generative AI. Dr. Maddox's work sits at the intersection of clinical care, informatics, operations, and technology. He is focused on implementing innovative technologies into clinical workflows in ways that are sustainable, scalable, and capable of delivering meaningful clinical and operational value. This includes translating real-time clinical and operational data into measurable improvements in hospital throughput, length of stay, patient safety, care transitions, chronic disease management, and the experience of clinicians and care teams. Previously, Dr. Maddox served as the founding Executive Director of the Healthcare Innovation Lab and as Vice President for Digital Products and Innovation at BJC HealthCare, where he led teams that built and scaled enterprise capabilities in care redesign, digital innovation, and technology-enabled transformation across a 15-hospital academic health system. Earlier in his career, he directed the national VA Clinical Assessment, Reporting, and Tracking program, overseeing cardiovascular quality and safety across VA cardiac catheterization laboratories nationwide. 

Dr. Maddox is also Professor of Medicine (Cardiology) at WashU Medicine, a practicing non-invasive cardiologist, and a board-certified clinical informatician. His academic work spans health services research, clinical registries, digital health, clinical informatics, and AI in medicine, with more than 270 peer-reviewed publications. His work has been supported by a range of funding organizations, including the NIH, the U.S. Department of Veterans Affairs, and AHRQ. Nationally, Dr. Maddox serves on the FDA Digital Health Advisory Committee and the National Academy of Medicine’s Digital Health & AI Action Collaborative. He is the Deputy Editor for AI at Circulation and recently completed a term on the American College of Cardiology Board of Trustees.